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Infectious Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5265
ISSN (Online): 2212-3989

Research Article

Clinical Evaluation of Febrile Thrombocytopenia in Western Rajasthan - a Hospital-based Study

Author(s): Sahadev Choudhary, Deepak Kumar*, Gopal K. Bohra, Alok Gupta, Durga S. Meena, Rajkumar Singh Rathore and Sunil K. Bhambu

Volume 20, Issue 5, 2020

Page: [718 - 723] Pages: 6

DOI: 10.2174/1871526519666191008113616

Price: $65

Abstract

A number of patients of febrile thrombocytopenia increase during monsoon and postmonsoon period. Diseases like dengue fever, malaria, chikungunya fever, etc. are responsible for the clustering of febrile thrombocytopenia cases during this period. The diagnosis of fever with thrombocytopenia cases can be challenging and physicians should be aware of the regional and endemic seasonal cause of this syndrome.

Study Design: It is a prospective observational study.

Material and Methods: The study included 103 consecutive patients. The patients admitted with acute febrile illness defined by a duration of less than 2 weeks with thrombocytopenia were evaluated.

Results: The present study included 103 consecutive cases of febrile thrombocytopenia. Out of these, 71.84% were male and 28.16% were female. The most common etiology for febrile thrombocytopenia was dengue fever (44.66%) and malaria (31.06%). Among clinical evaluation of the cases, fever was the inclusion criteria. Myalgia was the most common symptom found after fever, which was observed in 83.5% of the patients. The most common bleeding manifestation was petechiae/ purpura (12.62%) followed by hematuria (6.80%). Renal dysfunction was present in all 8(100%) cases of sepsis, followed by 14(43.75%) cases of malaria. All sepsis cases also had liver dysfunction, followed by 91.3% cases in dengue fever and 90.62 % cases in malaria had liver dysfunction.

Conclusion: The study showed that acute febrile thrombocytopenia is an important seasonal syndrome. The common causes are dengue fever and malaria. Early identification of these diseases and prompt treatment decreases complications and reduces mortality.

Keywords: Acute febrile thrombocytopenia, dengue fever, malaria, septicemia, hepatic dysfunction, renal dysfunction.

[1]
Patil, P.; Solanke, P.; Harshe, G. To study clinical evaluation and outcome of patients with febrile thrombocytopenia. Int J Sci Res Publ., 2014, 4, 2-3.
[2]
Mural, R.; Manohar, M.R. Study of clinical profile of thrombocytopenia. Int. J. Contemp. Med. Res., 2017, 4(9), 1886-1888.
[3]
Rani, R.V.; Sundararajan, T.; Rajesh, S.; Jeyamurugan, T. A study on common etiologies of acute febrile illness detectable by micro-biological tests in a tertiary care hospital. Int. J. Curr. Microbiol. Appl. Sci., 2016, 5, 670-674.
[http://dx.doi.org/10.20546/ijcmas.2016.507.076]
[4]
Shelke, Y.P.; Deotale, V.S.; Maraskolhe, D.L. Spectrum of infections in acute febrile illness in central India. Indian J. Med. Microbiol., 2017, 35(4), 480-484.
[http://dx.doi.org/10.4103/ijmm.IJMM_17_33] [PMID: 29405137]
[5]
Singer, M.; Deutschman, C.S.; Seymour, C.W.; Shankar-Hari, M.; Annane, D.; Bauer, M.; Bellomo, R.; Bernard, G.R.; Chiche, J.D.; Coopersmith, C.M.; Hotchkiss, R.S.; Levy, M.M.; Marshall, J.C.; Martin, G.S.; Opal, S.M.; Rubenfeld, G.D.; van der Poll, T.; Vincent, J.L.; Angus, D.C. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 2016, 315(8), 801-810.
[http://dx.doi.org/10.1001/jama.2016.0287] [PMID: 26903338]
[6]
Nair, P.S.; Jain, P.; Khanduri, U.; Kumar, V. A study of fever associated thrombocytopenia. J. Assoc. Physicians India, 2003, 51, 1173.
[7]
Pervin, M.; Tabassum, S.; Ali, M.M.; Mamun, K.Z.; Islam, M.N. Clinical and laboratory observations associated with the 2000 Dengue outbreak in Dhaka, Bangladesh. Dengue Bull., 2004, 28, 96-106.
[8]
Fah, T.S. MMed, N.A.; Liew, C.G.; Omar, K. Omar k. Clinical features of acute febrile thrombocytopenia among patients attending primary care clinics. Malays. Fam. Physician, 2006, 1(1), 15-18.
[PMID: 26998201]
[9]
Lohitashwa, S.B.; Vishwanath, B.M.; Srinivas, G.A. Study of Clinical and lab profile of fever with thrombocytopenia. J. Assoc. Physicians India, 2009, 57.
[10]
Guidelines for the use of platelet transfusions. Br. J. Haematol., 2003, 122(1), 10-23.
[http://dx.doi.org/10.1046/j.1365-2141.2003.04468.x] [PMID: 12823341]
[11]
Patel, M.L.; Himanshu, D.; Chaudhary, S.C.; Atam, V.; Sachan, R.; Misra, R.; Mohapatra, S.D. Clinical characteristic and risk factors of Acute Kidney Injury among Dengue viral infections in adults: A Retrospective Analysis. Indian J. Nephrol., 2019, 29(1), 15-21.
[PMID: 30814788]
[12]
Deshwal, R.; Qureshi, M.I.; Singh, R. Clinical and laboratory profile of Dengue fever. J. Assoc. Physicians India, 2015, 63(12), 30-32.
[PMID: 27666901]
[13]
Jadhav, U.M.; Patkar, V.S.; Kadam, N.N. Thrombocytopenia in malaria--correlation with type and severity of malaria. J. Assoc. Physicians India, 2004, 52, 615-618.
[PMID: 15847353]
[14]
Kochar, D.K.; Das, A.; Kochar, A.; Middha, S.; Acharya, J.; Tanwar, G.S.; Gupta, A.; Pakalapati, D.; Garg, S.; Saxena, V.; Subudhi, A.K.; Boopathi, P.A.; Sirohi, P.; Kochar, S.K. Thrombocytopenia in Plasmodium falciparum, Plasmodium vivax and mixed infection malaria: a study from Bikaner (Northwestern India). Platelets, 2010, 21(8), 623-627.
[http://dx.doi.org/10.3109/09537104.2010.505308] [PMID: 21050055]
[15]
Limaye, C.S.; Londhey, V.A.; Nabar, S.T. The study of complications of vivax malaria in comparison with falciparum malaria in Mumbai. J. Assoc. Physicians India, 2012, 60, 15-18.
[PMID: 23777019]
[16]
Lacerda, M.V.; Mourão, M.P.; Alexandre, M.A.; Siqueira, A.M.; Magalhães, B.M.; Martinez-Espinosa, F.E.; Filho, F.S.; Brasil, P.; Ventura, A.M.; Tada, M.S.; Couto, V.S.; Silva, A.R.; Silva, R.S.; Alecrim, M.G. Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature. Malar. J., 2012, 11, 12.
[http://dx.doi.org/10.1186/1475-2875-11-12] [PMID: 22230294]
[17]
Lee, K.H.; Hui, K.P.; Tan, W.C.; Lim, T.K. Klebsiella bacteraemia: a report of 101 cases from National University Hospital, Singapore. J. Hosp. Infect., 1994, 27(4), 299-305.
[http://dx.doi.org/10.1016/0195-6701(94)90117-1] [PMID: 7963472]

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