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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Synthesis and Reactivity of 7-Azaindoles (1H-Pyrrolo(2,3-b)pyridine)

Author(s): Jean-Yves Merour and Benoit Joseph

Volume 5, Issue 5, 2001

Page: [471 - 506] Pages: 36

DOI: 10.2174/1385272013375427

Price: $65


The results of research into the chemistry of 7-azaindole during the last twenty years are presented. New synthetic methods for the 7-azaindole structures are developed including palladium-catalysed cross-coupling reactions. Reactivity of 3-formyl-, 3-halogeno- and 2-lithio-7-azaindole derivatives is reported. Functionalisation of the pyridine ring via the N-oxide is also described. In the last part, biological activity of various 7-azaindole derivatives is briefly indicated.

Keywords: Azaindoles, palladium-catalysed, cross-coupling reactions, Kirkpatrickia varialosa, pyrrolo annelation, heteroatomic rings, butylcarbonylaminopyridine, photo-Graebe-Ullmann, intramolecular cyclisation, iminophosphorane moiety., functionalised aldehyde, iodomethame, monobrominated

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