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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

Joint Computational and Experimental Investigations on the Synthesis and Properties of Hantzsch-type Compounds: An Overview

Author(s): Tayebeh Hosseinnejad*, Marzieh Omrani-Pachin and Majid M. Heravi *

Volume 23, Issue 13, 2019

Page: [1421 - 1438] Pages: 18

DOI: 10.2174/1385272823666190808110837

Price: $65


In this review, we try to highlight the significance, mechanism propositions, computational and experimental assessments of Hantzsch dihydropyridine (DHPs) which readily oxidized to the corresponding pyridines as one of the most important aromatic heterocycles. We also try to give an overview to its ability in transfer hydrogenation, acting as hydride donors from computational and experimental points of view. Our survey is also extended to computational assessments on the structural and biological properties of Hantzsch DHPs.

Keywords: Hantzsch synthesis, dihydropyridines, computational chemistry, calcium channel blockers, asymmetric transfer hydrogenation, biological properties.

Graphical Abstract
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