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Recent Innovations in Chemical Engineering

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ISSN (Print): 2405-5204
ISSN (Online): 2405-5212

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Research Article

Optimization of Supercritical Fluid Extraction for Mariposa Christia Vespertilionis Leaves Towards Yield by Using Response Surface Methodology

Author(s): Mohd Azahar Mohd Ariff *, Nurul Nadiah Mohd Nazri, Noor Aina Abdul Razak, Mohamed Syazwan Osman and Jefri Jaapar

Volume 13, Issue 2, 2020

Page: [170 - 178] Pages: 9

DOI: 10.2174/2405520412666190807141906

Price: $65

Abstract

Background: Mariposa Christia Vespertilionis (L.) (MCV) Bakh. f. is a plant, commonly known as Mariposa or ‘butterfly wing’ due to the shape and color of its leaves which is similar to a butterfly. MCV has been known to be used as a treatment for many diseases such as tuberculosis, bronchitis, inflamed tonsils, colds, muscle weakness and poor blood circulation.

Methods: Supercritical Fluid Extraction (SFE) is the latest equipment that can be used for the extraction of MCV leaves. SFE is the process of separating one component from another by using supercritical fluids as the extraction media. SFE is widely used in extraction due to its environmental friendly process compared to conventional extraction technique.

Objective: The aim of this study was to obtain the most optimum conditions in terms of temperature, pressure and particle size in achieving the highest amount of yield in the MCV plant extract. Thus the manipulated parameters for this study were Temperature (T), Pressure (P) and Particle Size (S) where the ranges used were: temperature, T (°C): 30, 40, 50, 60, 70, pressure, P (bar): 150, 200, 250, 300, 350, and particle Size, S: 63 µm, 125 µm, 250 µm, 500 µm and 1 mm.

Results: To obtain the optimum condition of yield, Response Surface Methodology (RSM) was used. For the RSM design of experiment, 20 samples were run throughout this experiment.

Conclusion: The optimum parameter values generated from the RSM were 39°C for temperature, 202 bars for the pressure and 500 μm for the particle size with the yield of 7.9 %. Actual validation runs were carried out and the percentage error was 14 %.

Keywords: Optimization, mariposa christia vespertilionis, supercritical fluid extraction, response surface methodology, tuberculosis, extraction media.

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[1]
Bunawan SNH, Baharum SN. The red butterfly wing (Christia vespertilionis): A promising cancer cure in Malaysia. Int J Pharm Pharm Sci 2015; 7(8): 5.
[2]
Osman MS, Ghani ZA, Ismail NF, Razak NAA, Jaapar J, Ariff MAM. Qualitative comparison of active compounds between red and green Mariposa Christia Vespertillonis leaves extracts In: AIP Conf Proc. 2017; 1885.
[http://dx.doi.org/10.1063/1.5002476]
[3]
Upadhyay HC, Sisodia BS, Cheema HS, et al. Novel antiplasmodial agents from Christia vespertilionis. Nat Prod Commun 2013; 8(11): 1591-4.
[http://dx.doi.org/10.1177/1934578X1300801123] [PMID: 24427949]
[4]
Ariff MA, Abdul GZ. Supercritical CO2 extraction of red butterfly wing leaves: Process parametric study towards extraction yield. InMATEC Web of Conferences 2018 154: 01015.
[5]
Rebolleda MLS, Rubio N, Beltrán S, Sanz MT. González-sanjosé. Supercritical fluid extraction of corn germ oil: Study of the influence of process parameters on the extraction yield and oil quality. J Supercrit Fluids 2012; 72(1): 270-7.
[http://dx.doi.org/10.1016/j.supflu.2012.10.001]
[6]
Azmir AKMJ, Zaidul ISM, Rahman MM, Sharif KM, Mohamed A, Sahena FO. Techniques for extraction of bioactive compounds from plant materials: A review. J Food Eng 2013; 117(4): 426-36.
[http://dx.doi.org/10.1016/j.jfoodeng.2013.01.014]
[7]
Martín JSL, Mainar AM, González-Coloma A, Burillo JU. Supercritical fluid extraction of wormwood (Artemisia absinthium L.). J Supercrit Fluids 2011; 56(1): 64-71.
[http://dx.doi.org/10.1016/j.supflu.2010.11.017]
[8]
Sapkale GN, Patil SM, Surwase US, Bhatbhage PK. Supercritical fluid extraction. Intl J Chem Sci 2010; 8(2): 729-43.
[9]
Karbalaie YNS, Ghotbi C, Taghikhani VY. Experimental study and modeling of supercritical extraction of nicotine from tabacco leaves. Iran J Chem Chem Eng 2009; 28(4): 51-9.
[10]
Milić PS, Rajković KM, Stamenković OS, Veljković VB. Kinetic modeling and optimization of maceration and ultrasound-extraction of resinoid from the aerial parts of white lady’s bedstraw (Galium mollugo L.). Ultrason Sonochem 2013; 20(1): 525-34.
[http://dx.doi.org/10.1016/j.ultsonch.2012.07.017] [PMID: 22922037]
[11]
Jentzer JB, Alignan M, Vaca-Garcia C, Rigal L, Vilarem G. Response surface methodology to optimise accelerated solvent extraction of steviol glycosides from Stevia rebaudiana Bertoni leaves. Food Chem 2015; 166(2): 561-7.
[http://dx.doi.org/10.1016/j.foodchem.2014.06.078] [PMID: 25053094]
[12]
Puri M, Sharma D, Barrow CJ, Tiwary AK. Optimisation of novel method for the extraction of steviosides from Stevia rebaudiana leaves. Food Chem 2012; 132(3): 1113-20.
[http://dx.doi.org/10.1016/j.foodchem.2011.11.063] [PMID: 29243590]
[13]
Georgieva K, Dagnon S, Gesheva E, Bojilov D, Mihailova G, Doncheva S. Antioxidant defense during desiccation of the resurrection plant Haberlea rhodopensis. Plant Physiol Biochem 2017; 114(2): 51-9.
[http://dx.doi.org/10.1016/j.plaphy.2017.02.021] [PMID: 28268193]
[14]
Domingues CMRMA, De Melo MMR, Oliveira ELG, Neto CP, Silvestre AJDS. Optimization of the supercritical fluid extraction of triterpenic acids from Eucalyptus globulus bark using experimental design. J Supercrit Fluids 2013; 74(1): 105-14.
[http://dx.doi.org/10.1016/j.supflu.2012.12.005]
[15]
Rakić T, Kasagić-Vujanović I, Jovanović M, Jančić-Stojanović B, Ivanović D. Comparison of full factorial design, central composite design, and box-behnken design in chromatographic method development for the determination of fluconazole and its impurities. Anal Lett 2014; 47(8): 1334-47.
[http://dx.doi.org/10.1080/00032719.2013.867503]
[16]
Salar RK, Purewal SS, Bhatti MS. Optimization of extraction conditions and enhancement of phenolic content and antioxidant activity of pearl millet fermented with Aspergillus awamori MTCC-548. Resour Technol 2016; 2(3): 148-57.
[17]
Demirel BKM. Application of response surface methodology and central composite design for the optimization of textile dye degradation by wet air oxidation. Demirel Kayan Intl J Ind Chem 2012; 3(24): 1-10.
[http://dx.doi.org/10.1186/2228-5547-3-24]
[18]
Zgórka G. Pressurized liquid extraction versus other extraction techniques in micropreparative isolation of pharmacologically active isoflavones from Trifolium L. species. Talanta 2009; 79(1): 46-53.
[http://dx.doi.org/10.1016/j.talanta.2009.03.011] [PMID: 19376342]
[19]
Kulazynski M, Stolarski M, Faltynowicz H, Narowska B. Supercritical fluid extraction of vegetable materials. Chem Chem Technol 2016; 10(4): 637-43.
[20]
Zhao S, Zhang D. Supercritical CO2 extraction of Eucalyptus leaves oil and comparison with Soxhlet extraction and hydro-distillation methods. Sep Purif Technol J Chem Eng 2014; 133: 443-51.

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