Abstract
Leptin is an adipokine whose proinflammatory properties contribute to the pathogenesis of several autoimmune diseases but also to the development and progression of inflammation in several non-autoimmune inflammatory conditions of the kidney, liver, lung, endometrium, blood vessels and endothelia. Here we review the influences of leptin in those conditions and the pertinent experimental work that has defined some mechanisms of action and/or suggested a therapeutic potential for leptin-based modulation of inflammation in non-autoimmune conditions.
Keywords: Inflammation, leptin, hypothalamic neurons, Th1 and Th2 cytokines, Treg, Teff, STAT, Non-Autoimmune Conditions
Inflammation & Allergy - Drug Targets (Discontinued)
Title:Proinflammatory Activities of Leptin in Non-Autoimmune Conditions
Volume: 11 Issue: 4
Author(s): Antonio La Cava
Affiliation:
Keywords: Inflammation, leptin, hypothalamic neurons, Th1 and Th2 cytokines, Treg, Teff, STAT, Non-Autoimmune Conditions
Abstract: Leptin is an adipokine whose proinflammatory properties contribute to the pathogenesis of several autoimmune diseases but also to the development and progression of inflammation in several non-autoimmune inflammatory conditions of the kidney, liver, lung, endometrium, blood vessels and endothelia. Here we review the influences of leptin in those conditions and the pertinent experimental work that has defined some mechanisms of action and/or suggested a therapeutic potential for leptin-based modulation of inflammation in non-autoimmune conditions.
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Cite this article as:
La Cava Antonio, Proinflammatory Activities of Leptin in Non-Autoimmune Conditions, Inflammation & Allergy - Drug Targets (Discontinued) 2012; 11 (4) . https://dx.doi.org/10.2174/187152812800959031
DOI https://dx.doi.org/10.2174/187152812800959031 |
Print ISSN 1871-5281 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4055 |
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