Imaging techniques targeting tumor angiogenesis have been investigated for past decade. Of these, the radiolabeled Arg-Gly-
Asp (RGD) peptide has been focused because it has high affinity and selectivity for integrin alpha(v)beta3. Integrin alpha(v)beta3 is
expressed on the plasma membrane in an active status in which it binds its ligands and transduce signals when exposed activating
external stimuli of tumor angiogenesis such as vascular endothelial growth factor (VEGF). Many linear or cyclic RGD peptides were
developed for positron emission tomography (PET). In this review, we focused on currently developed RGD peptides as PET probes for
non-invasive detection of integrin alpha(v)beta3 expression.
Keywords: Integrin, integrin alpha(v)beta3, angiogenesis, VEGF, PET, positron emission tomography, PET/CT, RGD, radiolabeled-RGD, RGD peptide
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