Abstract
Native glycosidic bonds in carbohydrates, are sensitive to the presence of enzymes. Thus, design of small molecule mimics (glycomimetics) is an active area of research. This review will focus on the development of a new class of glycomimetics: anomeric and N-glycosyl sulfonamides. These novel compounds have been demonstrated to be enzyme inhibitors or antiproliferative agents.
Keywords: Glycomimetics, Anomeric sulfonamides, N-glycosyl sulfonamides, Carbohydrates, Enzyme Inhibition, galactofuranosyl sulfonamides, anomeric thiolacetates, 2, 4-dimethoxybenzyl, carbonic anhydrase isozymes, anti-cancer compounds, lipophilicity
Current Organic Chemistry
Title:Novel Glycomimetics: Anomeric and N-Glycosyl Sulfonamides
Volume: 16 Issue: 14
Author(s): Pedro A. Colinas
Affiliation:
Keywords: Glycomimetics, Anomeric sulfonamides, N-glycosyl sulfonamides, Carbohydrates, Enzyme Inhibition, galactofuranosyl sulfonamides, anomeric thiolacetates, 2, 4-dimethoxybenzyl, carbonic anhydrase isozymes, anti-cancer compounds, lipophilicity
Abstract: Native glycosidic bonds in carbohydrates, are sensitive to the presence of enzymes. Thus, design of small molecule mimics (glycomimetics) is an active area of research. This review will focus on the development of a new class of glycomimetics: anomeric and N-glycosyl sulfonamides. These novel compounds have been demonstrated to be enzyme inhibitors or antiproliferative agents.
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Cite this article as:
A. Colinas Pedro, Novel Glycomimetics: Anomeric and N-Glycosyl Sulfonamides, Current Organic Chemistry 2012; 16 (14) . https://dx.doi.org/10.2174/138527212800840892
DOI https://dx.doi.org/10.2174/138527212800840892 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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