Antiretroviral therapy (ART) in pregnant women represents a unique combination of therapy and prophylaxis of HIV infection.
Until the global epidemic of HIV and the discovery of efficient prevention of perinatal transmission through ART, the world has not
witnessed a pharmacologic intervention of such a scale during pregnancy and delivery. The use of ART in pregnancy creates unique challenges
in delivering therapeutic agents, targeting the HIV virus in both the pregnant woman and her unborn child, throughout dramatic
changes in their physiologic state. With an increased complexity of perinatal ART and the introduction of novel agents into clinical practice,
a better understanding of the pharmacokinetics (PK) and pharmacodynamics of ARV drugs is crucial for the safe and most effective
use of ARV drugs in women during pregnancy and infants in the first months of life. While PK studies are already difficult to perform
during pregnancy, they are particularly challenging in women with HIV infection due to multiple social, economic and cultural constrains.
In this paper we provide an overview of published studies of ART disposition during pregnancy, labor, breastfeeding and in the
newborn infant after delivery.
Keywords: Antiretroviral therapy, HIV, pregnancy, pharmacokinetics, infants, ART, PMTCT, MTCT, NVP
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Published on: 06 June, 2012
Page: [744 - 759]