Gestational Diabetes Affects Placental-Fetal Development
Pp. 88-96 (9)
Evemie Dubé, Cathy Vaillancourt, Julie Lafond and Louiza Belkacemi
Gestational diabetes mellitus occurs only during pregnancy, and usually disappears shortly
after delivery. Although, GDM is a common disorder, its pathophysiology is not well understood.
Impaired placental function is probably a contributing factor as the placenta hinders insulin signaling
and produce increased levels of cytokines that affect placental transport and metabolism of glucose and
lipids. This in turn negatively impacts on fetal growth and development with significantly increased risk
of a number of short-and long-term adverse consequences for the fetus, and the most significant of
which is a predisposition to the development of metabolic syndrome and Type 2 diabetes. This article
will describe placental changes in gestational diabetes related to glucose and lipids following placental
insulin and cytokines dysfunction, and subsequent effects on the offspring development.
Diabetes, gestation, glucose, receptors, lipids, insulin, cytokines.
Department of Sciences Biologiques, Université du Québec à Montréal, Montréal, Québec, Canada, H3C 3P8