Pregnancy Disorders and Perinatal Outcomes

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Pregnancy Disorders and Perinatal Outcomes offers readers insights into knowledge related to maternal habits or disorders that could affect fetal development and lead to disability later in childhood ...
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Immune System and Perinatal Outcomes

Pp. 74-87 (14)

Shigeru Saito


Pregnancy represents a semiallograft to a maternal host. To prevent semiallograft rejection, the maternal immune system dramatically changes to a unique immune system during pregnancy. Maladaptation of this system could cause implantation failure, recurrent spontaneous abortion, preeclampsia and preterm delivery. The objective of this report is to review the pathophysiology of these events in human pregnancy from the aspects of reproductive immunology.


Miscarriage, preeclampsia, pregnancy, preterm labor, reproductive immunology.


Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani Toyama-shi, Toyama 930- 0194 Japan