Chemoinformatics: Directions Toward Combating Neglected Diseases

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Low-income populations in developing regions of Africa, Asia and the Americas have been particularly injured by a group of tropical infections denominated neglected diseases. Compared to important ...
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An Overview of Tropical Parasitic Diseases: Causative Agents, Targets and Drugs

Pp. 174-196 (23)

Carlton Anthony Taft and Carlos Henrique Tomich de Paula da Silva

Abstract

There is a need for improved treatments for diseases including protozoan parasitic diseases, such as chagas, malaria, trypanosomiasis, leishmaniasis, onchocerciasis, schistosomiasis, filariasis, toxoplasmosis, cryptosporidiosis, filardiasis and giardiasis. The existing chemotherapy for these diseases is not sufficiently effective due to factors such as toxicity, drug resistance and different strain sensitivities. New chemotherapies are needed to help in the control and prevention of these parasitic diseases.

Keywords:

Tropical diseases, causative agents, drug targets.

Affiliation:

Centro Brasileiro de Pesquisas Físicas, Rua Dr. Xavier Sigaud, 150, Urca, 22290-180, Rio de Janeiro, Brazil