Implication of microRNAs in the Pathogenesis of MDS

Author(s): Jing Fang, Melinda Varney, Daniel T. Starczynowski

Journal Name: Current Pharmaceutical Design

Volume 18 , Issue 22 , 2012

Become EABM
Become Reviewer
Call for Editor


MicroRNAs (miRNAs) are significant regulators of human hematopoietic stem cells (HSC), and their deregulation contributes to hematological malignancies. Myelodysplastic syndromes (MDS) represent a spectrum of hematological disorders characterized by dysfunctional HSC, ineffective blood cell production, progressive marrow failure, and an increased risk of developing acute myeloid leukemia (AML). Although miRNAs have been primarily studied in AML, only recently have similar studies been performed on MDS. In this review, we describe the normal function and expression of miRNAs in human HSC, and describe mounting evidence that deregulation of miRNAs contributes to the pathogenesis of MDS.

Keywords: microRNA, Myelodysplastic syndrome, microarray, hematopoietic stem cells (HSC), acute myeloid leukemia (AML), epigenetic modifying drugs, chemotherapy, refractory anemia (RA), ringed sideroblasts (RARS), 5q- syndrome

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2012
Published on: 31 May, 2012
Page: [3170 - 3179]
Pages: 10
DOI: 10.2174/1381612811209023170
Price: $65

Article Metrics

PDF: 20