Intracellular Logistics of BST-2/Tetherin

Author(s): Hideaki Fujita, Keiko Fujimoto, Kenzo Tokunaga, Yoshitaka Tanaka

Journal Name: Current HIV Research
HIV and Viral Immune Diseases

Volume 10 , Issue 4 , 2012

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Bone marrow stromal antigen 2 (BST-2) is a type II membrane protein with two targeting signals, one of which is located in the cytoplasmic domain and contains a non-canonical dual tyrosine-based motif responsible for its endocytosis from the plasma membrane, and the other is a C-terminal glycosylphosphatidylinositol anchor that facilitates its association with detergent-resistant membranes/lipid rafts and targeting to the apical domain in polarized epithelial cells. Due to its unusual topology at the membrane, BST-2 takes unique and complicated trafficking routes in cells. Recently, a physiological role for BST-2 as the “tetherin” molecule for viruses, especially for HIV-1, has been extensively examined. These studies have shown that the biosynthesis, intracellular trafficking, localization, and structure of human BST-2 are closely related to its antiviral activity. This review provides an overview of the intracellular logistics of human BST-2.

Keywords: α-adaptin, BST-2, endocytosis, GPI-anchor, HIV-1, lipid raft, lysosome, ubiquitin ligase, Golgi, TGN

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Article Details

Year: 2012
Published on: 31 May, 2012
Page: [321 - 326]
Pages: 6
DOI: 10.2174/157016212800792522
Price: $65

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