Functionalized Mesoporous Silica Particles for Application in Drug Delivery System

Author(s): J. Pang, Y. Luan, X. Yang, Y. Jiang, L. Zhao, Y. Zong, Z. Li

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 12 , Issue 8 , 2012

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In these years, ordered mesoporous silica materials have shown promising applications in drug delivery system as drug carriers. These carriers with stable mesoporous structure, large surface area, good biocompatibility and tailored size of mesopores exhibit significant property of higher drug loading. However, silica-based mesoporous materials cannot control the release of the loaded drug without modifications. In this paper, we review the recent research work discussing functionalization of mesoporous materials by various components and methods for application in drug delivery systems. All the examples show that these functionalized mesoporous silica-based systems have great potential for a variety of drug delivery applications, specifically in the fields of the drug targeted and controlled delivery systems.

Keywords: Biocompatibility, drug delivery, mesoporous silica particles, modification.

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Article Details

Year: 2012
Published on: 29 May, 2012
Page: [775 - 788]
Pages: 14
DOI: 10.2174/138955712801264855
Price: $65

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