The Involvement of PPARs in the Causes, Consequences and Mechanisms for Correction of Cardiac Lipotoxicity and Oxidative Stress

Author(s): M. C. Sugden, M. P. Warlow, M. J. Holness

Journal Name: Current Molecular Pharmacology

Volume 5 , Issue 2 , 2012

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Chronically-elevated plasma lipid concentrations, particularly when combined with high glucose, elicit a plethora of effects that cause the progressive deterioration of insulin sensitivity and ultimately cellular malfunction or death. This review addresses how metabolic abnormalities in white adipose tissue leading to excessive lipid or abnormal adipokine release can be modified by PPARγ activation. It also discusses the etiology of cardiac lipotoxicity and oxidative stress, in relation to imbalanced lipid delivery and clearance and how PPARα activation can be used to correct some of these effects.

Keywords: PPARalpha, PPARgamma, SIRT, AMPK, lipotoxicity

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Article Details

Year: 2012
Published on: 21 May, 2012
Page: [224 - 240]
Pages: 17
DOI: 10.2174/1874467211205020224
Price: $65

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