Abstract
Intermittent parathyroid hormone (iPTH) is the only FDA-approved therapy for bone loss due to conditions such as osteoporosis that increases bone formation by osteoblasts; all other therapies approved for osteoporosis block bone resorption by osteoclasts. The anabolic effects of iPTH are likely due to a combination of multiple mechanisms, including induction of immediate-early genes, increased expression and/or activity of essential osteoblast transcription factors, and downregulation of anti-osteogenic proteins, such as sclerostin. In contrast, continuous administration of PTH induces bone loss primarily due to up-regulation of RANKL expression and inhibition of osteoprotegerin expression.
Keywords: Anabolic, immediate-early genes, osteoblast, osteoprotegerin, PTH, RANKL, sclerostin, transcription factors
Current Molecular Pharmacology
Title:Anabolic Effects of Intermittent PTH on Osteoblasts
Volume: 5
Author(s): Edward M. Greenfield
Affiliation:
Keywords: Anabolic, immediate-early genes, osteoblast, osteoprotegerin, PTH, RANKL, sclerostin, transcription factors
Abstract: Intermittent parathyroid hormone (iPTH) is the only FDA-approved therapy for bone loss due to conditions such as osteoporosis that increases bone formation by osteoblasts; all other therapies approved for osteoporosis block bone resorption by osteoclasts. The anabolic effects of iPTH are likely due to a combination of multiple mechanisms, including induction of immediate-early genes, increased expression and/or activity of essential osteoblast transcription factors, and downregulation of anti-osteogenic proteins, such as sclerostin. In contrast, continuous administration of PTH induces bone loss primarily due to up-regulation of RANKL expression and inhibition of osteoprotegerin expression.
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Cite this article as:
M. Greenfield Edward, Anabolic Effects of Intermittent PTH on Osteoblasts, Current Molecular Pharmacology 2012; 5 (2) . https://dx.doi.org/10.2174/1874467211205020127
DOI https://dx.doi.org/10.2174/1874467211205020127 |
Print ISSN 1874-4672 |
Publisher Name Bentham Science Publisher |
Online ISSN 1874-4702 |
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