Drugs in Pediatric Ischemic Stroke

Kimberly      Statler Bennett; Denise      C. Morita

Abstract

Traditionally, drug therapy for pediatric ischemic stroke has been extrapolated from adult guidelines and studies. This approach is not optimal due to important differences between adult and pediatric stroke (e.g. etiologies, maturation changes in hemostasis). Research in pediatric stroke is increasing, and pediatric specific management guidelines have recently become available. This manuscript summarizes available drug therapy recommendations for pediatric ischemic stroke. Both acute management and secondary stroke prevention are discussed, including antiplatelet, anticoagulant, and thrombolytic drugs. When relevant, recommendations from adult ischemic stroke guidelines and data from pediatric stroke studies are incorporated.

Keywords: Anticoagulation, pediatric, stroke, thrombolytic, secondary stroke, anticoagulant, antiplatelet, ACUTE MANAGEMENT, evidence-based guidelines, hemostatic systems