Role of Rab4 in Transport through the Endosomal System
Pp. 108-122 (15)
Emma Martinez Sanchez, Ioana Popa, Magda Deneka and Peter van der Sluijs
The endosomal system is a mosaic of highly dynamic interconnected organelles that serve many
physiological functions including nutrient uptake, regulation of cell polarity, migration and plasma
membrane remodeling. These widely divergent processes rely on the flawless transfer of cargo molecules
between the distinct endosomal subcompartments and is regulated by members of the rab family of small
GTPases and their effector networks. Here we provide an overview of the function of rab4, and the
machinery it deploys to regulating exocytic membrane trafficking from early endosomes.
Rab4a, Rab4b, Endosomes, Recycling, Domain.
University Medical Center Utrecht, The Netherlands