1-Methylhydantion is a compound, which was isolated from Oviductus Ranae for the first time. In our study,
we found that it showed good antitussive and anti-inflammatory activity. It is also the first report which illustrates the
antitussive activity of hydantion derivative. A series of hydantion derivatives were synthesized and evaluated for their
anti-inflammatory and antitussive activity in vivo. The pharmacological tests showed that compounds 7a, 7c and 7d have
good anti-inflammatory and antitussive activity compared to Ibuprofen and codeine. Compound 7a in particular showed
two-fold stronger anti-inflammatory activity than Ibuprofen.
Keywords: Anti-inflammatory activity, Antitussive activity, Biological activity, Hydantoin, Ibuprofen, Synthesis
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