Title:Synthesis, Antibacterial and Antifungal Activities of 3-Amino-5- methyl[1,1'-biphenyl]-2,4-dicarbonitrile Derivatives
VOLUME: 9 ISSUE: 6
Author(s):Khalid Mohammed Khan, Waqas Jamil, Nida Ambreen, Afroze Amyn, Summaya Saied, Maria Kanwal, Aqeel Ahmed and Shahnaz Perveen
Affiliation:H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
Keywords:3-Amino-5-methyl-2, 4-dicarbonitrile biphenyl derivatives, Antibacterial, Antifungal
Abstract:3-Amino-5-methyl-2,4-dicarbonitrile biphenyl derivatives 1-14 have been synthesized and all compounds were
screened for their antibacterial effects against fourteen Gram-positive and sixteen Gram-negative bacterial strains and
showed varying degree of activities. Compounds 1, 2, 4, 5, 6, 8, 13, and 14 were found to be significantly active against
various Gram-positive bacteria, however, compounds 1, 3, 4, 6, 9, 12, and 13 were found to be significantly active against
various Gram-negative bacterial strains. These compounds were also screened against fourteen fungal strains but showed
weak activities against some fungal strains.
