Psychiatry is a specialty where the application of pharmacogenomics approaches is made to the study of interindividual
differences in response to antidepressants. It is highly applied for improving patient treatment. Major
depressive disorder (MDD) is a common and complex disorder resulting from genetic and environmental interactions.
Less than 40% of patients with MDD achieve remission, and even after several treatment trials, one in three patients do
not fully recover from MDD. Many clinical and genomic association studies suggested that the catechol-Omethyltransferase
(COMT) gene region was an important genetic locus for psychiatric disorders, because of the proposed
relationship between its function in catecholaminergic neurotransmission and individual response to antidepressants, and
vulnerability to psychiatric disorders. Although a number of COMT single nucleotide polymorphisms (SNPs) were
observed, the Val108/158Met (rs4680) polymorphism in exon 4 resulted in a change in the enzyme structure which has
been intensively investigated in relation to its role of enzyme activity and processes of prefrontal cortex functions in
cognition. As serotonin interacts with dopamine and dopamine availability is influenced by COMT SNPs, an association
between the COMT gene and response to treatment, based on the various pharmacogenetics/pharmacogenomics studies
about COMT gene published to date, is explored in this overview.
Keywords: COMT gene, pharmacogenetics, antidepressant, treatment response, snp, Catechol O Methyl Transferase, Major Depressive disorder , COMT, MDD, rs4680, Antidepressant treatment, Dopamine
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