Radiation, chemotherapy, and surgery share roles in modern cancer therapy targeting neoplastic tumor cells.
Greater understanding of the importance of angiogenesis and tumor neovascularization in oncology has led to development
of another therapeutic modality, angiogenesis inhibitors, which specifically target the tumor vasculature. Antiangiogenic
agents have been shown to act synergistically with traditional cytotoxic treatments, including radiation, against a variety
of tumor histologies. Their selective incorporation in multimodality therapy based on tumor type, angiogenic profile,
and individual patient response offers the potential for greater disease control. In this review we summarize studies evaluating
angiogenesis inhibitors combined with radiation in cancer therapy, and progress made towards optimally incorporating
these agents into established treatment regimens.
Keywords: Angiogenesis, antiangiogenic therapy, angiogenesis inhibitors, radiotherapy, Multimodality Cancer Therapy, neoplastic tumor cells, tumor neovascularization, regimens
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Published on: 13 May, 2012
Page: [157 - 167]