The pseudotrisaccharide allosamidin 1 is a potent family-18 chitinase inhibitor, and it demonstrates biological
activities against insects and fungi. Recent development for the synthesis and activities of compound 1 and its analogues
was reviewed. Huang et al. described the solid-phase synthesis of allosamidin 1 and its analogues, which were obtained
by iterative glycosylation reactions, catalytic hydrogenation, acetylation, and deacetylation, respectively. It indicated that
di-N-acetyl-β-chitobiosyl allosamizoline was strongly against insect chitinase from Bombyx mori. Withers and his coworkers
have synthesized chitobiose and chitotriose thiazolines, which exhibit chitinase inhibition activity.
Keywords: Allosamidin, analogues, synthesis, activities, recent development, β-linked, N-iodosuccinimide, oligosaccharides, trimethylsilyl trifluromethanesulfonate
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