Recent Progress on Synthesis and Activities of Allosamidin and Its Analogues

Author(s): Gangliang Huang

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 12 , Issue 7 , 2012

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The pseudotrisaccharide allosamidin 1 is a potent family-18 chitinase inhibitor, and it demonstrates biological activities against insects and fungi. Recent development for the synthesis and activities of compound 1 and its analogues was reviewed. Huang et al. described the solid-phase synthesis of allosamidin 1 and its analogues, which were obtained by iterative glycosylation reactions, catalytic hydrogenation, acetylation, and deacetylation, respectively. It indicated that di-N-acetyl-β-chitobiosyl allosamizoline was strongly against insect chitinase from Bombyx mori. Withers and his coworkers have synthesized chitobiose and chitotriose thiazolines, which exhibit chitinase inhibition activity.

Keywords: Allosamidin, analogues, synthesis, activities, recent development, β-linked, N-iodosuccinimide, oligosaccharides, trimethylsilyl trifluromethanesulfonate

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Article Details

Year: 2012
Page: [665 - 670]
Pages: 6
DOI: 10.2174/138955712800626700
Price: $65

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