UDP-glucuronosyltransferases (UGTs) play important roles in the disposition of many drugs and xenobiotics. Herbal medicine,
an important group of multicomponent therapeutics, is widely and increasingly used. Drug metabolism of herbal medicine mediated
by cytochrome P450s has been extensively studied; however, herbal medicine metabolism mediated by UGTs has not been adequately
investigated. Thus, it is necessary to evaluate current evidence on the glucuronidation of herbal medicines by UGTs. In this review, the
research advances of the potential for commonly used herbal medicines as UGT substrate and modulator are summarized. In addition, the
herb-drug interactions associated with UGTs are also discussed.
Keywords: UDP-glucuronosyltransferase, herbal medicines, glucuronidation, herb-drug interaction, Phytochemical Metabolism, Associated Herb-Drug Interactions, UGTs, multicomponent therapeutics, Drug metabolism, herbal medicine, cytochrome P450s, glucuronidation, morphine
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