Title:Natural Products Based Anticancer Agents
VOLUME: 9 ISSUE: 2
Author(s):Biswanath Das and Gandham Satyalakshmi
Affiliation:Organic Chemistry Division – I, Indian Institute of Chemical Technology, Hyderabad – 500007, Organic Chemistry Division – I, Indian Institute of Chemical Technology, Hyderabad – 500007
Keywords:Natural products, anticancer compounds, sources, bioactivities, mode of action, structure-activity relationship, commercial drugs, Podophyllotoxin, Viblastine, Vincristine, Campotothecin, Taxol, Discodermolide
Abstract:Natural products have been a rich source of anticancer compounds. Several anticancer “lead” compounds have been isolated
and identified from different natural sources. These lead compounds after proper chemical modifications and bioevaluations afforded potential
drugs. In the present article the sources, chemistry and bioactivities of some promising natural anticancer compounds have been
discussed. The structure-activity relationship of these natural products and the discovery of useful drugs derived from them have also
been highlighted.
