Natural Products Based Anticancer Agents

Author(s): Biswanath Das, Gandham Satyalakshmi

Journal Name: Mini-Reviews in Organic Chemistry

Volume 9 , Issue 2 , 2012

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Natural products have been a rich source of anticancer compounds. Several anticancer “lead” compounds have been isolated and identified from different natural sources. These lead compounds after proper chemical modifications and bioevaluations afforded potential drugs. In the present article the sources, chemistry and bioactivities of some promising natural anticancer compounds have been discussed. The structure-activity relationship of these natural products and the discovery of useful drugs derived from them have also been highlighted.

Keywords: Natural products, anticancer compounds, sources, bioactivities, mode of action, structure-activity relationship, commercial drugs, Podophyllotoxin, Viblastine, Vincristine, Campotothecin, Taxol, Discodermolide

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Article Details

Year: 2012
Published on: 08 May, 2012
Page: [169 - 177]
Pages: 9
DOI: 10.2174/157019312800604706

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PDF: 43