Bio-Activities and Syntheses Developments of Triptolides

Author(s): Shi-Wu Chen, Ni-Ni Zhou, Chong Li

Journal Name: Mini-Reviews in Organic Chemistry

Volume 9 , Issue 2 , 2012

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Abstract:

Tripterygium wilfordii Hook.f. has a long history of use in traditional Chinese medicine. The diterpene triepoxide triptolide 1, as the main bioactive constituent of Tripterygium extracts, has been used to treat a variety of autoimmune, inflammation-related conditions and neurodegenerative diseases, and it also displays antiinflammatory activity, antiproliferative and apoptotic effects, antifertility and insecticidal activity. Several synthetic studies and structure-activity relationships (SAR) have been carried out on triptolide as well as others structurally related molecules. This review focused on the biological and pharmacological activities, total syntheses and their structure-activity relationships of triptolide and congeners.

Keywords: Tripterygium, Triptolide, Diterpene, Antiinflammatory, Anticancer, Spondylitis, Systemic lupus erythematosus, TWHF, iNOS, Tamelens method, Alvarez-manzanedas method, Lactone ring

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2012
Page: [151 - 162]
Pages: 12
DOI: 10.2174/157019312800604661
Price: $65

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