Title:Bio-Activities and Syntheses Developments of Triptolides
VOLUME: 9 ISSUE: 2
Author(s):Shi-Wu Chen, Ni-Ni Zhou and Chong Li
Affiliation:School of Pharmacy, Lanzhou University, Lanzhou, 730000, China.
Keywords:Tripterygium, Triptolide, Diterpene, Antiinflammatory, Anticancer, Spondylitis, Systemic lupus erythematosus, TWHF, iNOS, Tamelens method, Alvarez-manzanedas method, Lactone ring
Abstract:Tripterygium wilfordii Hook.f. has a long history of use in traditional Chinese medicine. The diterpene triepoxide triptolide 1,
as the main bioactive constituent of Tripterygium extracts, has been used to treat a variety of autoimmune, inflammation-related conditions
and neurodegenerative diseases, and it also displays antiinflammatory activity, antiproliferative and apoptotic effects, antifertility
and insecticidal activity. Several synthetic studies and structure-activity relationships (SAR) have been carried out on triptolide as well as
others structurally related molecules. This review focused on the biological and pharmacological activities, total syntheses and their
structure-activity relationships of triptolide and congeners.
