The paper focuses on optimizing layout of obstacles for enhanced mixing in microchannels. The obstacles can
hinder fluid flow and alter the flow direction. In this case, the mixing performance can be achieved further effectively.
Three parameters including geometric configuration, layout, and number of obstacles have been studied for analyzing
mixing in a ‘T’ channel. In order to facilitate the design, numerical simulations and orthogonal experiment were used to
study the effect of three parameters on sensitivity of mixing. The degree of sensitivity using the Taguchi method can be
ranked as: asymmetric layout > number of obstacles > geometric configuration. Placing obstacles in the microchannels is
an effective method for enhancing mixing and the micromixer with obstacles is relatively easy to produce using standard
microfabrication techniques. It can be demonstrated that the results should facilitate the design of microfluidic device.