The catalytic C-C bond activation by rhodium complexes has found a wide application in organic synthesis. The
course of the reaction is usually controlled by the proper ligand environment enabling processes that are otherwise not
feasible under classical conditions of organic chemistry. The C-C bond activation can be achieved by the release of ringstrain
in cycloalkanes (e.g. compounds possessing three- and four-membered rings), in case of non-strained C-C bonds it
could be directed by a neighboring functionality (e.g. carbonyl group), or through initial C-H activation (e.g. aldehyde decarbonylation).
Many of these processes have been implemented in syntheses of various natural compounds. The use of
chiral ligands has recently enabled to carry many of these reactions in an enantioselective manner.
Keywords: Rhodium, C-C bond cleavage, Catalysis, Synthesis, σ-orbitals, C–Rh bond, C–C bond activation, norbornadiene, monodentate, cyclopropyl group
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