Background: To investigate whether features of muscular complaints (MC) differ between receivers of a statin
prescription and non-receivers. To analyze the relationship between analgesics prescription, statin prescription and/or
Methods: Cross-sectional study. Consecutive patients in offices of family practitioners were interviewed using a
standardized questionnaire. Target variables: Rates of features of MC in patients with or without a statin prescription and
rates of analgesic drug prescription in patients with or without statin prescription and/or musculoskeletal disorders. Odds
ratios (adjusted for age, sex, and socio-economic status) were calculated using logistic regression analysis.
Results: 1135 patients in 26 general practitioners’ offices were asked to participate, and 1031 patients agreed. Features of MC
did not differ between the two groups of patients. Analgesic prescription was found to be associated with statin prescription in
patients without musculoskeletal disorders (OR 2.2, CI 1.1-4.7 without statin, OR 2.5, CI 0.9-6.9 with statin) and particularly
in those with musculoskeletal disorders (OR 5.2, CI 2.9-9.3 without statin, OR 9.3, CI 4.5-19.1 with statin).
Conclusions: Analgesic prescriptions are probably positively associated with statin prescription. Assuming that analgesics
attenuate MC, an even stronger association between MC and statin use seems likely. The results generate the hypothesis
that statin use contributes to analgesic use in primary care patients.