Background: Mineralocorticoids are thought to play a role in tissue repair, including fibrous tissue formation.
The antimineralocorticoid activity of spironolactone has been linked to an increased risk of gastrointestinal bleeding.
Drospirenone is a synthetic progestin approved in combination with ethinyl-estradiol as an oral contraceptive (OC). It is a
spironolactone-derivative, and its antimineralocorticoid effects could irritate the gastrointestinal tract leading to symptoms
of irritable bowel syndrome (IBS).
Methods: A retrospective cohort study was conducted evaluating women 18-46 years of age in the IMS claims-database.
New-users of progestin-based OCs were identified between 1997-2009. Ninety days of OC therapy and one year of prior
enrollment with no prior diagnosis of IBS were required for inclusion. Cases were identified using a previously validated
method for the diagnosis of IBS. Cox proportional hazards models were used to estimate the hazard ratio (HR) for
developing IBS with the different OC formulations using levonorgestrel as a reference.
Results: The cohort included 939,281 women, averaging 29.1 years of age and 247 days of OC therapy. 3,050 incident
cases of IBS were detected. The annualized incidence for IBS with drospirenone was 0.77% (1083 cases) while that for
levonorgestrel was 0.46% (483 cases). The crude HR for development of IBS with drospirenone compared to
levonorgestrel was 1.70 (95%CI 1.53-1.90), while the adjusted HR was 1.63 (95%CI 1.46-1.82). Multiple sensitivity
analyses confirmed this association. Other OCs were unassociated with IBS.
Conclusion: Our study found a positive association between drospirenone and a diagnosis of IBS that was not observed
with other OCs.