Cardiac Effects of HDL and Its Components on Diabetic Cardiomyopathy

Author(s): Frank Spillmann, Sophie Van Linthout, Carsten Tschope

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
(Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders)

Volume 12 , Issue 2 , 2012

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Diabetic cardiopathy includes a specific cardiomyopathy, which occurs in the absence of coronary heart disease and hypertension under diabetes mellitus. Hyperglycemia, hyperinsulinemia, and hyperlipidemia, characteristic metabolic disturbances evident in diabetes mellitus, all three lead to a specific altered cardiac structure and function. Recently, it has been demonstrated that altered HDL, be it low HDL or dysfunctional HDL is not only a consequence of diabetes mellitus, but can also contribute to the development of diabetes mellitus, and therefore also of diabetic cardiomyopathy. This review summarizes how HDL can indirectly affect diabetic cardiomyopathy via their influence on the metabolic triggers hyperglycemia, hyperinsulinemia, and hyperlipidemia, and how they can directly influence the cardiac cellular consequences, typical for diabetic cardiomyopathy, including inflammation, oxidative stress, apoptosis, fibrosis, Ca2+ handling, glucose homeostasis, and endothelial dysfunction.

Keywords: Diabetes mellitus, dysfunction, endothelial dysfunction, glucose metabolism, high-density lipoprotein, remodeling

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Article Details

Year: 2012
Page: [132 - 147]
Pages: 16
DOI: 10.2174/187153012800493521
Price: $65

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PDF: 16