Pathogenesis of Atherosclerotic Plaque
Pp. 5-6 (2)
S. Novo, G.R. Amoroso, F. Bonura, P. Carità, E. Corrado and G. Novo
The ATS is a slow-progressive process involving arteries with large and medium diameter. It seems to
result both from an immune and inflammatory reaction and several studies have shown the endothelial reaction to
various injuries as the main mechanism involved in the development of the focal atherosclerotic wall lesions.
These lesions initially do not obstruct the blood flow. However, thrombotic events can occur and cause ischemia
of the region supplied by the injured artery. The vulnerable plaque (eccentric, non stenotic, with a thin fibrous cap
and big lipid core, rich of inflammatory and smooth muscle cells) is a particular type of lesion which can easily
lead to complications.
Endothelial dysfunction, foam cells, fatty streaks, pre-atheroma, atheroma, fibro-atheroma, vulnerable
plaque, hemorrhage, rupture, thrombosis.
Department of Internal Medicine and Cardiovascular Diseases, University of Palermo – Italy