Pulmonary Hypertension and Right Ventricular Dysfunction in Chronic Lung Diseases: New Pathobiologic Concepts

Author(s): Jose Gomez-Arroyo, Herman J. Bogaard, Laszlo Farkas, Antonio Abbate, Norbert F. Voelkel

Journal Name: Current Respiratory Medicine Reviews

Volume 8 , Issue 2 , 2012

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Here we provide background information for the pathobiological concept of a “sick lung circulation”, and how it may affect cardiac function. We propose that in most chronic and progressive lung diseases, but in particular COPD/emphysema and interstitial lung diseases (ILD), there are significant pathological changes of the small pulmonary vessels. Complementing the WHO classification of pulmonary vascular diseases we provide a classification which is based on pathogenetic mechanisms such as inflammation, hypoxia and angioproliferation. We also propose that chronic lung disease – related ‘cor pulmonale’ is insufficiently explained by an elevation of the pulmonary arterial pressure.

Keywords: COPD, emphysema, lung vascular remodeling, HIF-1 &agr;, VEGF, endothelial-mesenchyma transition [EnMT], “sick lung circulation”

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Article Details

Year: 2012
Published on: 29 April, 2012
Page: [116 - 122]
Pages: 7
DOI: 10.2174/157339812799859798
Price: $65

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