Generic placeholder image

Current Enzyme Inhibition

Editor-in-Chief

ISSN (Print): 1573-4080
ISSN (Online): 1875-6662

Cytotoxic Natural Products and their Pharmacological Mode of Action: A Hypothesis on their Complexity and Spectrum of Activity

Author(s): Jacob E. John

Volume 8, Issue 1, 2012

Page: [100 - 103] Pages: 4

DOI: 10.2174/157340812800228946

Price: $65

Abstract

Natural products are important in pharmaceutical research, and many medicines are based on natural products. It is estimated that about 40% of all medicines and about 60% of anti-cancer agents are based on natural products. Plants, marine organisms, amphibians and soil micro-organisms produce cytotoxic compounds to protect themselves or their micro-environment against other organisms and species. It may be beneficial if such cytotoxic natural products affect target enzymes across a broad spectrum of organisms and species.

Keywords: Cytotoxic, natural product, inhibition, conformations, drug binding-site, vinca alkaloids, tubulin, tropical diseases, streptomycin, 3D-QSAR


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy