Natural products are important in pharmaceutical research, and many medicines are based on natural products. It is estimated that about 40% of all medicines and about 60% of anti-cancer agents are based on natural products. Plants, marine organisms, amphibians and soil micro-organisms produce cytotoxic compounds to protect themselves or their micro-environment against other organisms and species. It may be beneficial if such cytotoxic natural products affect target enzymes across a broad spectrum of organisms and species.
Keywords: Cytotoxic, natural product, inhibition, conformations, drug binding-site, vinca alkaloids, tubulin, tropical diseases, streptomycin, 3D-QSAR
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