Cytotoxic Natural Products and their Pharmacological Mode of Action: A Hypothesis on their Complexity and Spectrum of Activity

Author(s): Jacob E. John

Journal Name: Current Enzyme Inhibition

Volume 8 , Issue 1 , 2012

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Natural products are important in pharmaceutical research, and many medicines are based on natural products. It is estimated that about 40% of all medicines and about 60% of anti-cancer agents are based on natural products. Plants, marine organisms, amphibians and soil micro-organisms produce cytotoxic compounds to protect themselves or their micro-environment against other organisms and species. It may be beneficial if such cytotoxic natural products affect target enzymes across a broad spectrum of organisms and species.

Keywords: Cytotoxic, natural product, inhibition, conformations, drug binding-site, vinca alkaloids, tubulin, tropical diseases, streptomycin, 3D-QSAR

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Article Details

Year: 2012
Page: [100 - 103]
Pages: 4
DOI: 10.2174/157340812800228946

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PDF: 18