Synthesis and Preliminary Antihyperlipidaemic Activities Evaluation of Andrographolide Derivatives

Author(s): Bin Wang, Chunlei Tang, Yaodan Han, Ruzhou Guo, Hai Qian, Wenlong Huang

Journal Name: Medicinal Chemistry

Volume 8 , Issue 2 , 2012

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Recent studies indicated that andrographolide was a potential antihyperlipidaemic therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their antihyperlipidaemic activities were evaluated in vivo. As compared with TG, TC, HDL-C and LDL-C concentrations, some of the derivatives exhibited better antihyperlipidaemic effects than positive control atromide. Therein, compound 6i, which was the most potent compound, could serve as a new lead for further development of antihyperlipidaemic agents.

Keywords: andrographolide, antihyperlipidaemic activities, derivatives, synthesis, Cholesterol, hyperlipidemia, Green tea, Artichoke, Guggul, plants

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Article Details

Year: 2012
Published on: 27 April, 2012
Page: [293 - 298]
Pages: 6
DOI: 10.2174/157340612800493629
Price: $65

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