Deformable Surfactant Vesicles Loading Ammonium Glycyrrhizinate: Characterization and In Vitro Permeation Studies

Luisa Di Marzio, Carlotta Marianecci, Federica Rinaldi, Sara Esposito, Maria Carafa

Abstract

This study focuses on the physico-chemical characterization of surfactant nanovectors according to the evidence that the knowledge of nanocarrier properties is a necessary step to translate their potentiality to nanomedicine applications. In particular, in this investigation we have prepared deformable surfactant vesicles (dSV) and characterized them in terms of dimensions, zeta-potential, deformability index and stability. Also the potential application of analyzed carriers is evaluated in terms of ammonium glycyrrhizinate (AG) entrapment efficiency and in vitro permeation experiments. The obtained results suggest the potential application of dSV in dermal administration of AG, a useful drug for the treatment of various skin diseases, such as dermatitis, eczema and psoriasis.

Keywords: plant-derived drugs, Glycyrrhiza glabra L, Medicinal plants, Leguminosae, perennial, Triterpene saponins, corticosteroids, psoriasis, eczema, glycyrrhizin