A Novel Practical Synthesis of Pazopanib: An Anticancer Drug

Author(s): YiCheng Mei, BaoWei Yang, Wei Chen, DanDan Huang, Ying Li, Xin Deng, BaoMing Liu, JingJie Wang, Hai Qian, WenLong Huang

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 4 , 2012

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This paper reports a novel approach to synthesize pazopanib. In our synthetic route, the potently mutagenic alkylating agents such as dimethyl sulfate and methyl iodide are avoided. A novel regioselective methylation of the 2- position of 3-methyl-6-nitro-1H-indazole was reported. This novel route is one step shorter than the previously reported route.

Keywords: Anticancer drug, pazopanib, regioselective methylation, synthesis, trimethyl orthoformate, vasculature, dichloropyrimidine, chloride, methylene

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Article Details

Year: 2012
Published on: 24 April, 2012
Page: [276 - 279]
Pages: 4
DOI: 10.2174/157017812800233714

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