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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Myocardial Structure and Matrix Metalloproteinases

Author(s): C. Aggeli, P. Pietri, I. Felekos, L. Rautopoulos, K. Toutouzas, E. Tsiamis and C. Stefanadis

Volume 12, Issue 10, 2012

Page: [1113 - 1131] Pages: 19

DOI: 10.2174/1568026611208011113

Abstract

Metalloproteinases (MMPs) are enzymes which enhance proteolysis of extracellular matrix proteins. The pathophysiologic and prognostic role of MMPs has been demonstrated in numerous studies. The present review covers a wide a range of topics with regards to MMPs structural and functional properties, as well as their role in myocardial remodeling in several cardiovascular diseases. Moreover, the clinical and therapeutic implications from their assessment are highlighted.

Keywords: Metaloproteinases, myocardial structure, extracellular matrix proteins, prognostic role of MMPs, numerous studies, myocardial remodeling, cardiovascular diseases, clinical and therapeutic implications, left ventricular (LV), cardiac remodeling, cardiomyopathy, clinical and therapeutic implications, cell surface proteins, fibrillar collagens


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