Abstract
Metalloproteinases (MMPs) are enzymes which enhance proteolysis of extracellular matrix proteins. The pathophysiologic and prognostic role of MMPs has been demonstrated in numerous studies. The present review covers a wide a range of topics with regards to MMPs structural and functional properties, as well as their role in myocardial remodeling in several cardiovascular diseases. Moreover, the clinical and therapeutic implications from their assessment are highlighted.
Keywords: Metaloproteinases, myocardial structure, extracellular matrix proteins, prognostic role of MMPs, numerous studies, myocardial remodeling, cardiovascular diseases, clinical and therapeutic implications, left ventricular (LV), cardiac remodeling, cardiomyopathy, clinical and therapeutic implications, cell surface proteins, fibrillar collagens
Current Topics in Medicinal Chemistry
Title:Myocardial Structure and Matrix Metalloproteinases
Volume: 12 Issue: 10
Author(s): C. Aggeli, P. Pietri, I. Felekos, L. Rautopoulos, K. Toutouzas, E. Tsiamis and C. Stefanadis
Affiliation:
Keywords: Metaloproteinases, myocardial structure, extracellular matrix proteins, prognostic role of MMPs, numerous studies, myocardial remodeling, cardiovascular diseases, clinical and therapeutic implications, left ventricular (LV), cardiac remodeling, cardiomyopathy, clinical and therapeutic implications, cell surface proteins, fibrillar collagens
Abstract: Metalloproteinases (MMPs) are enzymes which enhance proteolysis of extracellular matrix proteins. The pathophysiologic and prognostic role of MMPs has been demonstrated in numerous studies. The present review covers a wide a range of topics with regards to MMPs structural and functional properties, as well as their role in myocardial remodeling in several cardiovascular diseases. Moreover, the clinical and therapeutic implications from their assessment are highlighted.
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Aggeli C., Pietri P., Felekos I., Rautopoulos L., Toutouzas K., Tsiamis E. and Stefanadis C., Myocardial Structure and Matrix Metalloproteinases, Current Topics in Medicinal Chemistry 2012; 12 (10) . https://dx.doi.org/10.2174/1568026611208011113
DOI https://dx.doi.org/10.2174/1568026611208011113 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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