Recent Advance in the Pharmacology of Dihydropyrimidinone

Author(s): J.-P. Wan, Y. Pan

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 12 , Issue 4 , 2012

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Dihydropyrimidinones (DHPMs) are a series of highly valuable small molecules possessing versatile pharmaceutical properties. Although the first one-pot synthesis of DHPMs had been reported more than 100 years ago, the fascinating achievement in DHPMs-based pharmacology during the past century promoted durative interests to the pharmacological and related studies of the scaffold, which lead to the discovery of many new biological functions of DHPMs. Recent pharmacological development on DHPMs-based molecules have been summarized in this review.

Keywords: Dihydropyrimidinone, pharmacology, enzyme/mitotic kinesin inhibitor, receptor antagonist, calcium channel blocker, adrenoceptor, Rho-associated, serine-threonine, polypeptides, kinesin

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Article Details

Year: 2012
Page: [337 - 349]
Pages: 13
DOI: 10.2174/138955712799829267
Price: $65

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