Title:Heparin - a Key Drug in the Treatment of the Circulatory Degenerative Diseases: Controlling its Action with Polymers
VOLUME: 18 ISSUE: 18
Author(s):Krzysztof Szczubialka, Kamil Kaminski, Katarzyna Zasada, Anna Karewicz and Maria Nowakowska
Affiliation:Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland.
Keywords:Heparin, anticoagulation, unfractionated heparin, low molecular weight heparin, heparin reversal, noninvasive delivery, heparinotherapy, heparin inhibition, polymeric substances, glycosaminoglycans (GAGs)
Abstract:The properties of heparin, a key anticoagulant, are reviewed. The important issues in heparinotherapy, i.e., reaching quick anticoagulant
effect, maintaining therapeutic level of anticoagulation, heparin inhibition and non-invasive heparin formulations have been
reviewed and discussed, with the focus on the role of polymeric substances in the proposed solutions.
