Title:Glutamatergic Neurotransmission As Molecular Target of New Anticonvulsants
VOLUME: 12 ISSUE: 9
Author(s):Rosaria Gitto, Laura De Luca, Sara De Grazia and Alba Chimirri
Affiliation:Dipartimento Farmaco- Chimico, Universita di Messina, Viale Annunziata, 98168 Messina, Italy.
Keywords:AMPA, anticonvulsants, epilepsy, glutamate, glutamate transporters, iGluR, mGluR
Abstract:Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) controlling
physiological processes as learning and memory. However, the overactivation of glutamatergic neurotransmission is often
related to various CNS chronic and acute diseases (epilepsy, ischaemia, Parkinson, etc.). This review will focus on the
chemical structures, mechanism of action and main structure-activity relationships of anticonvulsant agents acting through
glutamate neurotransmission.
