Non Pharmacological Therapies in the Management of Osteoarthritis

Indexed in: Scopus, EBSCO.

Osteoarthritis is a chronic disease prevalent among the elderly. Its most prominent feature is the progressive destruction of articular cartilage which results in impaired joint motion, severe pain ...
[view complete introduction]

US $

*(Excluding Mailing and Handling)

Acupuncture and Osteoarthritis: Practices and Evidences

Pp. 81-93 (13)

DOI: 10.2174/978160805317911201010081

Author(s): K. Sanchez, S. Poiraudeau, F. Rannou


Acupuncture is recommended as a non-pharmacological treatment option for patients with knee and hip osteoarthritis (OA). Acupuncture is a Chinese philosophy which aims to restore the body to normal health. The explained mechanisms consider that acupuncture nociceptive pathways are essential for acupuncture analgesia, which is mediated by different endogenous neurotransmitters, such as enkephalin and dynorphin, and probably decreases the local inflammatory response via N-methyl-daspartate receptors. Acupuncture increases pain threshold gradually, with a peak effect at 20-40 min; a tolerance mediated by choleystokinin octapeptide could be observed if a prolonged period of acupuncture stimulation is performed. Immunocytochemistry and imaging studies indicate that both pain and acupuncture activate the hypothalamicpituitary-adrenocortical axis.

The literature review shows that clinical effects are small when acupuncture is compared with sham for treating OA patients; however, few if any other commonly used treatments for OA meet the threshold for clinically relevant benefits. On the other hand, acupuncture exceeds the thresholds for clinical relevance when compared with a waiting list control and with some other active treatment control, but the absence of sham treatment as a control suggests that benefits are primarily due to expectation or placebo effects.


Osteoarthritis, acupuncture, pain.