Free Radicals and Related Reactive Species in Aging
Pp. 232-241 (10)
Y. Robert Li
Aging is a universal, complicated biological process characterized by the progressive
accumulation in an organism of diverse, deleterious changes with time that increase the chance of
disease and death. Although the molecular mechanisms of aging remain elusive, increasing evidence
suggests a critical role for free radicals and related reactive species, especially reactive oxygen species
in the process of aging. This chapter provides an overview of the evidence from both experimental
models and human subjects that supports an oxidative stress mechanism of aging.
Aging, Antioxidant intervention, Catalase, Lifespan, Longevity, Nrf2, Oxidative stress, p66SHC,
Paraoxonase 1, Reactive oxygen species, Sirtuins.
Virginia Tech Corporate Research Center Blacksburg, Virginia USA