Free Radicals and Related Reactive Species in Cancer
Pp. 217-231 (15)
Y. Robert Li
Cancer remains a leading cause of death in the human population worldwide. Both genetic
and environmental factors are involved in the development of cancer. Recent work also demonstrates a
critical role for reactive oxygen and nitrogen species (ROS/RNS) in multistage carcinogenesis. This
chapter examines the oxidative stress mechanism of carcinogenesis as well as antioxidant-based
modalities for cancer intervention. The chapter also discusses ROS as a potential tumor killing modality
in cancer therapy.
Antioxidant intervention, Cancer, Carcinogens, Initiation, Multistage carcinogenesis, Oxidative
stress, Progression, Promotion, Reactive nitrogen species, Reactive oxygen species.
Virginia Tech Corporate Research Center Blacksburg, Virginia USA