Free Radical Biomedicine: Principles, Clinical Correlations, and Methodologies

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Free radicals and related reactive species, including reactive oxygen and nitrogen species (ROS/RNS) play a critical role in the pathophysiological processes of various human diseases, including ...
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Free Radicals and Related Reactive Species in Cancer

Pp. 217-231 (15)

Y. Robert Li


Cancer remains a leading cause of death in the human population worldwide. Both genetic and environmental factors are involved in the development of cancer. Recent work also demonstrates a critical role for reactive oxygen and nitrogen species (ROS/RNS) in multistage carcinogenesis. This chapter examines the oxidative stress mechanism of carcinogenesis as well as antioxidant-based modalities for cancer intervention. The chapter also discusses ROS as a potential tumor killing modality in cancer therapy.


Antioxidant intervention, Cancer, Carcinogens, Initiation, Multistage carcinogenesis, Oxidative stress, Progression, Promotion, Reactive nitrogen species, Reactive oxygen species.


Virginia Tech Corporate Research Center Blacksburg, Virginia USA