Free Radical Biomedicine: Principles, Clinical Correlations, and Methodologies

Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, Scopus, EBSCO.

Free radicals and related reactive species, including reactive oxygen and nitrogen species (ROS/RNS) play a critical role in the pathophysiological processes of various human diseases, including ...
[view complete introduction]

US $

*(Excluding Mailing and Handling)

Free Radicals and Related Reactive Species in Renal Diseases

Pp. 202-216 (15)

Y. Robert Li


Kidney diseases are broadly classified into acute kidney injury and chronic kidney disease. They collectively affect approximately 10% of the adult population in the United States and worldwide, and represent a major issue of public health. As our understanding of the pathophysiology of kidney diseases becomes more advanced, various new mechanistically-based therapeutic strategies for treating these diseases have been developed. This chapter summarizes experimental and clinical evidence supporting a causative role of oxidative stress in the pathophysiology of both acute kidney injury and chronic kidney disease. It also discusses the recent development of antioxidant-based intervention of kidney disorders.


Acute kidney injury, Antioxidant intervention, Chronic kidney disease, Nephrotoxicity, Oxidative stress, Reactive nitrogen species, Reactive oxygen species, Renal diseases.


Virginia Tech Corporate Research Center Blacksburg, Virginia USA