Free Radicals and Related Reactive Species in Hepatic and Gastrointestinal Diseases
Pp. 173-201 (29)
Y. Robert Li
Due to their essential roles in diverse physiological processes, the liver and the
gastrointestinal system are the major sites of many common diseases. Multiple pathophysiological
mechanisms have been identified to underlie various hepatic and gastrointestinal disorders. This chapter
discusses the oxidative stress mechanism in the disease processes of hepatic and gastrointestinal
systems and introduces antioxidant-based modalities for the disease intervention. The disease entities
covered in the chapter include alcoholic fatty liver disease, nonalcoholic fatty liver disease, Wilson’s
disease, liver ischemia-reperfusion injury, drug/xenobiotic-induced hepatotoxcity, inflammatory bowel
disease, peptic ulcer disease and Helicobacter pylori infection, and gastroesophageal reflux disease.
Alcoholic fatty liver disease, Antioxidant intervention, Gastroesophageal reflux disease,
Gastrointestinal diseases, Helicobacter pylori, Hepatic diseases, Hepatotoxicity, Inflammatory bowel
disease, Liver ischemia-reperfusion injury, Nonalcoholic fatty liver disease, Oxidative stress, Peptic ulcer
disease, Reactive nitrogen species, Reactive oxygen species, Wilson’s disease.
Virginia Tech Corporate Research Center Blacksburg, Virginia USA