Free Radicals and Related Reactive Species in Diabetes Mellitus and Metabolic Syndrome
Pp. 113-126 (14)
Y. Robert Li
Both diabetes mellitus (often simply referred to as diabetes) and metabolic syndrome are
prevalent metabolic disorders that pose significant impact on public health. Development of these metabolic
disorders involves the complex interactions between genes and environment, and the exact underlying
pathophysiology remains to be fully elucidated. Extensive studies in animal models provide ample evidence
for oxidative stress as an important pathophysiological component of both diabetes and metabolic
syndrome. In line with experimental studies, observational epidemiological studies and interventional
clinical trials suggest that oxidative stress may also play an important role in the pathophysiology of diabetes
and metabolic syndrome in humans. The increasing recognition of the involvement of oxidative stress in
diabetes and metabolic syndrome has prompted extensive research to develop antioxidant-based approaches
to the preventive and therapeutic intervention of these prevalent metabolic disorders.
Antioxidant intervention, Diabetes, Metabolic syndrome, Obesity, Oxidative stress, Reactive
nitrogen species, Reactive oxygen species.
Virginia Tech Corporate Research Center Blacksburg, Virginia USA