Carbon Monoxide, A Two-Face for the Protection of the Liver

Author(s): Florian Bosch, Tung Yu Tsui

Journal Name: Current Pharmaceutical Biotechnology

Volume 13 , Issue 6 , 2012

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Carbon monoxide is generally believed to be a ‘toxic’ gas molecule due to its binding capability with hemoglobin. Overexposure to carbon monoxide leads to a hypoxic state that may cause the death of a mammalian. In contrast, directly exposure of carbon monoxide may protect cells or organs from various disease insults. The paradox effects of carbon monoxide might vary on the ways of exposure and the amounts being exposed. Here we highlighted the characteristics of this gas molecule and summarized its protective effects and therapeutic potentials in liver diseases and liver transplantation.

Keywords: HO-1, CO, liver, IRI, cirrhosis, transplantation

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Article Details

Year: 2012
Published on: 18 April, 2012
Page: [803 - 812]
Pages: 10
DOI: 10.2174/138920112800399040
Price: $65

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