Abstract
Drug delivery through skin is the major confrontation due to its exceptional barrier properties. Despite major research and development efforts in transdermal systems, low Stratum corneum permeability limits the usefulness of topically administered drugs. This problem is more pronounced with bioactive drugs, which require special formulation technologies to overcome stability issues, their effective localization and safe release. This has led to an increased attention towards effective lipid based topical cutaneous systems. This review provides a brief overview of different lipid based systems, their associated advantages and disadvantages with special emphasis on lipid matrix systems like lipid microspheres or lipospheres and the potential of lipid matrix systems for transdermal delivery of bioactives.
Keywords: Bioactives, lipospheres, microspheres, solid lipid, topical/transdermal delivery, lipid matrix
Current Drug Delivery
Title:Lipid Matrix Systems with Emphasis on Lipid Microspheres: Potent Carriers for Transcutaneous Delivery of Bioactives
Volume: 9 Issue: 3
Author(s): Manju Rawat Singh, Kusum Pradhan and Deependra Singh
Affiliation:
Keywords: Bioactives, lipospheres, microspheres, solid lipid, topical/transdermal delivery, lipid matrix
Abstract: Drug delivery through skin is the major confrontation due to its exceptional barrier properties. Despite major research and development efforts in transdermal systems, low Stratum corneum permeability limits the usefulness of topically administered drugs. This problem is more pronounced with bioactive drugs, which require special formulation technologies to overcome stability issues, their effective localization and safe release. This has led to an increased attention towards effective lipid based topical cutaneous systems. This review provides a brief overview of different lipid based systems, their associated advantages and disadvantages with special emphasis on lipid matrix systems like lipid microspheres or lipospheres and the potential of lipid matrix systems for transdermal delivery of bioactives.
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Cite this article as:
Rawat Singh Manju, Pradhan Kusum and Singh Deependra, Lipid Matrix Systems with Emphasis on Lipid Microspheres: Potent Carriers for Transcutaneous Delivery of Bioactives, Current Drug Delivery 2012; 9 (3) . https://dx.doi.org/10.2174/156720112800389124
DOI https://dx.doi.org/10.2174/156720112800389124 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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